In secondary intention healing, the wound is intentionally left open to allow the body's natural healing processes to take place. This is common in wounds with extensive tissue loss, infection, or those that cannot be easily closed due to their nature.

A skin substitute is applied and the wound healing process begins by the formation of granulation tissue. Granulation tissue is a type of connective tissue that forms at the wound site, filling the gap left by the injury. This tissue is rich in blood vessels and serves as a foundation for further tissue repair.

Over time, new epithelial cells migrate across the wound surface, gradually covering the exposed tissue. This process, known as epithelialization, continues until the wound is completely covered with new skin.

Wounds healing by Secondary Intention with skin substitute support may require careful monitoring and proper wound care. Healthcare professionals may need to regularly assess the wound for signs of infection, ensure a healing environment, and provide appropriate skin substitute support for the healing process.